Mantenere attivo un blog dedicato ad un argomento specifico costa fatica e comporta l’utilizzo di risorse che, allo stato, non è possibile sostenere. In attesa di tempi migliori il blog “Neurosal” non verrà aggiornato. Grazie a quanti hanno voluto seguirlo finora.

Impulse Control Disorders are associated with REM Sleep Behavior Disorder in patients with Parkinson’s Disease: a Video-Polysomnographic Study.
Poster presented by Maria Livia Fantini, Maurizio Zibetti, Michela Figorilli, Beudin Patricia,Ana Marques,Debilly Bérangère,Derost Philippe,Miguel Ulla,Nicolas Vitello,Tiphaine Vidal, Monica Puligheddu, Alessandro Cicolin, Leonardo Lopiano, Franck Durif
OBJECTIVE: to compare the frequency of REM Sleep Behavior Disorder (RBD) diagnosed by video-polysomnography in patients with Parkinson’s Disease (PD) with and without impulse control disorder (ICDs).
BACKGROUND: in a recent study we have shown that patients with PD and clinical probable RBD have an increased risk to develop symptoms of ICDs as assessed by questionnaire.
METHODS: twenty-six consecutive non-demented PD patients [18M; mean age: 64.9±9.1 yrs., Hohen &Yahr (H&Y):2.2±0.5] with one or more current ICDs (PD-ICDs) were identified during their routine evaluation at two movement disorders centers. The presence of ICDs was assessed through a detailed clinical interview and diagnosis was made according to standard criteria. PD-ICDs patients were matched by sex and age with 26 consecutive PD patients without history of ICDs (PD-noICDs, mean age: 64.3±9.1 yrs, H&Y: 2.3±0.6). All subjects underwent to a full-night video-polysomnographic recording (vPSG). Sleep scoring was performed blindly to ICDs condition and RBD was diagnosed according to ICDS-3 criteria, including a quantified measure of REM sleep without Atonia (RSWA).
RESULTS: RBD was found in 23/26 (88.0%) PD-ICDs patients vs. 13/26 (50.0%) PD-no ICDs patients (Fisher-exact test: p=0.006). Mean RSWA in PD-ICDs and PD-noICDs was 53.6±26.2% and 32.6±28.9% respectively (p=0.04). Two of the three PD-ICDs patients, failing to fulfill the RBD diagnostic criteria, showed very short motor episodes during REM sleep at video-monitoring, possibly suggesting a minor RBD.
CONCLUSION: in the present study, vPSG-diagnosed RBD was found in nearly 90% of PD patients with ICDs and in 50% of the PD-noICDs. These results confirm our previous findings and suggest that RBD might represent a predisposing factor for ICDs in PD.

Ad oggi non erano presenti in letteratura dati sull’utilizzo della zonisamide nel trattamento dei pazienti parkinsoniani in stadio iniziale. A colmare la lacuna il lavoro pubblicato su Neurology and Clinical Neuroscience (link) che evidenzia un miglioramento sia delle disfunzioni motorie che del sonno nei pazienti non trattati (de novo). Gli effetti benefici del trattamento si sono presentati a 1-2 mesi. Il trattamento, stando ai primi dati, sembrerebbe efficace anche sul sintomo tremore.I

In current issue of Neurology (link)
EARLY SYMPTOM BURDEN PREDICTS RECOVERY AFTER SPORT-RELATED CONCUSSION
The authors conducted a prospective cohort study of patients in a sports concussion clinic using recursive partitioning analysis to develop a multivariate prediction model to identify athletes at risk for a prolonged recovery from concussion. Their findings showed that the only independent predictor of prolonged symptoms after sport-related concussion was overall symptom burden.
ADIPONECTIN AND LEPTIN LEVELS IN MIGRAINEURS IN THE ATHEROSCLEROSIS RISK IN COMMUNITIES STUDY
The authors showed that adiponectin levels were higher in older individuals with migraine compared to those without migraine; however, after adjustments, levels remained significant only in older men. Attention to age and sex differences in migraine research may help unveil important and biologically plausible associations.
EPITOPE SPREADING AS AN EARLY PATHOGENIC EVENT IN PEDIATRIC MULTIPLE SCLEROSIS
Using antigen microarrays, including CNS-related proteins, lipids, and other autoantigens, the authors examined early immunologic events at clinical onset of pediatric multiple sclerosis. The findings in this cohort of patients with pediatric-onset CNS demyelinating diseases point to an active process of epitope spreading during early stages of multiple sclerosis, not seen in monophasic CNS inflammatory conditions.
THE SPEED OF ULTRAEARLY HEMATOMA GROWTH IN ACUTE INTRACEREBRAL HEMORRHAGE
Pooling data from 2 clinical trials of intracerebral hemorrhage showed a direct relationship between the degree of hemorrhage at onset and poor outcome, and the benefits of early intensive blood pressure lowering. As in ischemic stroke, time matters in acute intracerebral hemorrhage, and early control of blood pressure improves the chance of recovery.
ALTERED FUNCTIONAL CONNECTIVITY IN SEIZURE ONSET ZONES REVEALED BY FMRI INTRINSIC CONNECTIVITY
This article identified areas with abnormal functional connectivity that matched well with intracranial EEG seizure onset zones in the surgical group. This finding suggests that functional connectivity changes may help localize seizure foci in epilepsy.
MOTORIC COGNITIVE RISK SYNDROME: MULTICENTER INCIDENCE STUDY
The authors examined incidence rates of motoric cognitive risk syndrome in 3,128 adults aged 60 years and older who were dementia-free at baseline. With the incidence of motoric cognitive risk syndrome higher in older adults, the identification of modifiable risk factors will pinpoint high-risk individuals and help develop new interventions to prevent dementia.

In current number of Neurodegenerative disease (link):
Failure of Ubiquitin Proteasome System: Risk for Neurodegenerative DiseasesThe ubiquitin proteasome system (UPS) is the primary proteolytic quality control system in cells and has an essential function in the nervous system. UPS dysfunction has been linked to neurodegenerative conditions, including Alzheimer’s, Parkinson’s and Huntington’s diseases. The pathology of neurodegenerative diseases is characterized by the abnormal accumulation of insoluble protein aggregates or inclusion bodies within neurons. The failure or dysregulation of the UPS prevents the degradation of misfolded/aberrant proteins, leading to deficient synaptic function that eventually affects the nervous system. In this review, we discuss the UPS and its physiological roles in the nervous system, its influence on neuronal function, and how UPS dysfunction contributes to the development of neurodegenerative diseases.
Frontal Corpus Callosum Alterations in Progressive Supranuclear Palsy but Not in Parkinson’s Disease DTI identified a PSP-associated microstructural alteration pattern in the frontal lobes and in the CC area II including the corresponding bilateral callosal radiation tracts that could not be identified in both control samples, supporting the prominent PSP-associated frontal involvement as a potential neuroimaging marker.